Entity Central Index Key
Lessee operating lease liability payments due year five and thereafter.
Income tax reconciliation intellectual property transfer.
Tax cuts and jobs act of 2017 change in state apportionment tax reform and other.
Income Tax Reconciliation Permanent and other including share based payments excess deductions.
Cover [Abstract]
Document Type
Document Type
Amendment Flag
Amendment Flag
Document Period End Date
Document Period End Date
Document Fiscal Year Focus
Document Fiscal Year Focus
Document Fiscal Period Focus
Document Fiscal Period Focus
Trading Symbol
Trading Symbol
Entity Registrant Name
Entity Registrant Name
Entity Central Index Key
Current Fiscal Year End Date
Current Fiscal Year End Date
Entity Filer Category
Entity Filer Category
Entity Small Business
Entity Small Business
Entity Emerging Growth Company
Entity Emerging Growth Company
Entity Ex Transition Period
Entity Ex Transition Period
Entity Shell Company
Entity Shell Company
Entity Common Stock, Shares Outstanding
Entity Common Stock Shares Outstanding
Entity Well-known Seasoned Issuer
Entity Well Known Seasoned Issuer
Entity Voluntary Filers
Entity Voluntary Filers
Entity Public Float
Entity Public Float
Entity Current Reporting Status
Entity Current Reporting Status
Entity File Number
Entity File Number
Entity Tax Identification Number
Entity Tax Identification Number
Entity Address, Address Line One
Entity Address Address Line1
Entity Address, City or Town
Entity Address City Or Town
Entity Address, State or Province
Entity Address State Or Province
Entity Address, Postal Zip Code
Entity Address Postal Zip Code
City Area Code
City Area Code
Local Phone Number
Local Phone Number
Entity Interactive Data Current
Entity Interactive Data Current
Title of 12(b) Security
Security12b Title
Security Exchange Name
Security Exchange Name
Entity Incorporation, State or Country Code
Entity Incorporation State Country Code
Document Annual Report
Document Annual Report
Document Transition Report
Document Transition Report
ICFR Auditor Attestation Flag
Icfr Auditor Attestation Flag
Development derivative liabilities current.
Development derivative liabilities noncurrent.
Statement Of Financial Position [Abstract]
Assets
Assets [Abstract]
Current assets:
Assets Current [Abstract]
Cash and cash equivalents
Cash And Cash Equivalents At Carrying Value
Marketable securities
Marketable Securities Current
Prepaid assets
Prepaid Expense Current
Restricted cash
Restricted Cash Current
Other current assets
Other Assets Current
Total current assets
Assets Current
Non-current assets:
Assets Noncurrent [Abstract]
Right-of-use assets
Operating Lease Right Of Use Asset
Property and equipment, net
Property Plant And Equipment Net
Other assets
Other Assets Noncurrent
Total assets
Assets
Liabilities and Stockholders' Equity
Liabilities And Stockholders Equity [Abstract]
Current liabilities:
Liabilities Current [Abstract]
Accounts payable
Accounts Payable Current
Accrued expenses
Accrued Liabilities Current
Current portion of development derivative liability
Development Derivative Liabilities Current
Current portion of right-of-use liabilities
Operating Lease Liability Current
Total current liabilities
Liabilities Current
Long-term liabilities:
Liabilities Noncurrent [Abstract]
Convertible senior notes
Convertible Debt Noncurrent
Development derivative liability
Development Derivative Liabilities Noncurrent
Right-of-use liabilities
Operating Lease Liability Noncurrent
Total liabilities
Liabilities
Commitments and contingencies (note 15)
Commitments And Contingencies
Stockholders' equity:
Stockholders Equity [Abstract]
Preferred stock, $0.0001 par value; 10,000 shares authorized and zero shares issued and outstanding at December 31, 2020 and 2019
Preferred Stock Value
Common stock, $0.0001 par value; 200,000 shares authorized at December 31, 2020 and 2019; 76,130 and 63,938 shares issued and outstanding at December 31, 2020 and 2019, respectively
Common Stock Value
Additional paid-in capital
Additional Paid In Capital
Accumulated other comprehensive loss
Accumulated Other Comprehensive Income Loss Net Of Tax
Accumulated deficit
Retained Earnings Accumulated Deficit
Total stockholders' equity
Stockholders Equity
Total liabilities and stockholders' equity
Liabilities And Stockholders Equity
Preferred stock, par value
Preferred Stock Par Or Stated Value Per Share
Preferred stock, shares authorized
Preferred Stock Shares Authorized
Preferred stock, issued
Preferred Stock Shares Issued
Preferred stock, outstanding
Preferred Stock Shares Outstanding
Common stock, par value
Common Stock Par Or Stated Value Per Share
Common stock, shares authorized
Common Stock Shares Authorized
Common stock, issued
Common Stock Shares Issued
Common stock, outstanding
Common Stock Shares Outstanding
License expense.
Interest expense nonoperating.
Income Statement [Abstract]
Statement [Table]
Statement [Table]
Product and Service
Product Or Service [Axis]
Product and Service
Products And Services [Domain]
License [Member]
License [Member]
Collaboration.
Collaboration [Member]
Collaboration [Member]
Statement [Line Items]
Statement [Line Items]
Revenue:
Revenues [Abstract]
Revenue
Revenue From Contract With Customer Excluding Assessed Tax
Operating expenses:
Operating Expenses [Abstract]
Research and development
Research And Development Expense
License expense
License Expense
General and administrative
General And Administrative Expense
Operating expenses:
Operating Expenses
Net operating loss
Operating Income Loss
Loss on extinguishment of debt
Gains Losses On Extinguishment Of Debt
Loss from remeasurement of development derivative liability
Derivative Gain Loss On Derivative Net
Interest income
Investment Income Nonoperating
Interest expense
Interest Expense Nonoperating
Other expense, net
Other Nonoperating Income Expense
Net loss before taxes
Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest
Income tax expense
Income Tax Expense Benefit
Net loss
Net Income Loss
Other comprehensive income/(loss):
Other Comprehensive Income Loss Net Of Tax Period Increase Decrease [Abstract]
Unrealized loss on marketable securities
Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Net Of Tax
Foreign currency gain/(loss)
Other Comprehensive Income Loss Foreign Currency Transaction And Translation Adjustment Net Of Tax
Total other comprehensive income/(loss)
Other Comprehensive Income Loss Net Of Tax Portion Attributable To Parent
Comprehensive loss, net of tax
Comprehensive Income Net Of Tax
Net loss per common share, basic and diluted
Earnings Per Share Basic And Diluted
Weighted-average number of common shares used in net loss per common share, basic and diluted
Weighted Average Number Of Share Outstanding Basic And Diluted
Stock issued during period shares stock options or warrant exercise.
Stock issued during period value stock options or warrant exercised.
Adjustments to additional paid in capital purchase of capped call transactions and associated costs.
Statement Of Stockholders Equity [Abstract]
Equity Components
Statement Equity Components [Axis]
Equity Component
Equity Component [Domain]
Common Stock [Member]
Common Stock [Member]
Additional Paid-In Capital [Member]
Additional Paid In Capital [Member]
Accumulated Other Comprehensive Loss [Member]
Accumulated Other Comprehensive Income [Member]
Accumulated Deficit [Member]
Retained Earnings [Member]
Beginning balance
Beginning balance, Shares
Shares Outstanding
Issuance of common stock in follow-on offering, net of offering costs
Stock Issued During Period Value New Issues
Issuance of common stock in follow-on offering, shares
Stock Issued During Period Shares New Issues
Issuance of common stock upon exercise of stock options
Stock Issued During Period Value Stock Options Exercised
Issuance of common stock upon exercise of stock options, shares
Stock Issued During Period Shares Stock Options Exercised
Issuance of common stock upon exercise of stock options or warrants
Stock Issued During Period Value Stock Options Or Warrant Exercised
Issuance of common stock upon exercise of stock options or warrants, Shares
Stock Issued During Period Shares Stock Options Or Warrant Exercised
Recognition of equity component of convertible notes
Adjustments To Additional Paid In Capital Equity Component Of Convertible Debt
Purchase of capped call transactions and associated costs
Adjustments To Additional Paid In Capital Purchase Of Capped Call Transactions And Associated Costs
Share-based compensation expense
Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value
Issuance of common stock to employee stock purchase plan
Stock Issued During Period Value Employee Stock Purchase Plan
Issuance of common stock to employee stock purchase plan, shares
Stock Issued During Period Shares Employee Stock Purchase Plans
Net loss
Ending balance
Ending balance, Shares
Non cash lease expense.
Amortization of discounts for promissory note.
Amortization of term loan facility discounts.
Amortization of discounts for convertible notes, net of financing costs.
Proceeds from development derivative liability.
Payments for capped call transactions and associated costs.
Proceeds from issuance of convertible notes net of issuance costs.
Proceeds from stock options and warrants exercised.
Statement Of Cash Flows [Abstract]
Operating Activities
Net Cash Provided By Used In Operating Activities [Abstract]
Net loss
Profit Loss
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract]
Share-based compensation expense
Share Based Compensation
Loss on early extinguishment of debt
Loss from remeasurement of development derivative liability
Non-cash lease expense
Non Cash Lease Expense
Depreciation expense
Depreciation
Amortization of debt discounts
Amortization Of Debt Discount Premium
Amortization of discounts for promissory note
Amortization Of Discounts For Promissory Note
Amortization of term loan facility discounts
Amortization Of Term Loan Facility Discounts
Amortization of discounts for convertible notes, net of financing costs
Amortization Of Discounts For Convertible Notes Net Of Financing Costs
Changes in operating assets and liabilities:
Increase Decrease In Operating Capital [Abstract]
Prepaid assets
Increase Decrease In Prepaid Expense
Other current assets
Increase Decrease In Other Current Assets
Other assets
Increase Decrease In Other Noncurrent Assets
Accounts payable
Increase Decrease In Accounts Payable
Accrued expenses
Increase Decrease In Accrued Liabilities
Other liabilities
Increase Decrease In Other Noncurrent Liabilities
Net cash used in operating activities
Net Cash Provided By Used In Operating Activities
Investing Activities
Net Cash Provided By Used In Investing Activities [Abstract]
Purchase of property and equipment
Payments To Acquire Property Plant And Equipment
Purchase of available-for-sale securities
Payments To Acquire Available For Sale Securities
Proceeds from maturity of available-for-sale securities
Proceeds From Maturities Prepayments And Calls Of Available For Sale Securities
Net cash used in investing activities
Net Cash Provided By Used In Investing Activities
Financing Activities
Net Cash Provided By Used In Financing Activities [Abstract]
Deferred issuance costs
Payments Of Stock Issuance Costs
Proceeds from issuance of common stock, net of issuance costs
Proceeds From Issuance Of Common Stock
Proceeds from development derivative liability
Proceeds From Development Derivative Liability
Payments for capped call transactions and associated costs
Payments For Capped Call Transactions And Associated Costs
Proceeds from issuance of convertible notes, net of issuance costs
Proceeds From Issuance Of Convertible Notes Net Of Issuance Costs
Proceeds from exercise of stock options and warrants
Proceeds From Stock Options And Warrants Exercised
Proceeds from issuance of common stock under employee share purchase plan
Proceeds From Stock Plans
Repayment of promissory note
Repayments Of Notes Payable
Repayment of term loan facility
Repayments Of Long Term Lines Of Credit
Net cash provided by financing activities
Net Cash Provided By Used In Financing Activities
Effect of exchange rate changes on cash and cash equivalents
Effect Of Exchange Rate On Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents
Net increase in cash and cash equivalents
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect
Cash, cash equivalents and restricted cash at beginning of period
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents
Cash, cash equivalents and restricted cash at end of period
Equity component of convertible notes.
Reconciliation of cash, cash equivalents and restricted cash to the consolidated balance sheets:
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents [Abstract]
Restricted cash
Restricted Cash
Supplemental disclosure of cash flow information:
Supplemental Cash Flow Information [Abstract]
Cash paid for interest
Interest Paid Net
Equity component of convertible notes
Equity Component Of Convertible Notes
Documents Incorporated by Reference
Documents Incorporated By Reference [Text Block]
Organization Consolidation And Presentation Of Financial Statements [Abstract]
Nature of Organization and Operations
Nature Of Operations
Accounting Policies [Abstract]
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Equity [Abstract]
Common Stock
Stockholders Equity Note Disclosure [Text Block]
Development derivative liability disclosure.
Research And Development [Abstract]
Development Derivative Liability
Development Derivative Liability Disclosure [Text Block]
Accrued expenses and prepaid assets.
Accrued expenses and prepaid assets.
Accrued Expenses And Prepaid Assets [Abstract]
Accrued Expenses and Prepaid Assets
Accrued Expenses And Prepaid Assets [Text Block]
Debt Disclosure [Abstract]
Long-term Debt
Debt Disclosure [Text Block]
Leases [Abstract]
Leases
Lessee Operating Leases [Text Block]
Investments Debt And Equity Securities [Abstract]
Marketable Securities
Investments In Debt And Marketable Equity Securities And Certain Trading Assets Disclosure [Text Block]
Other Comprehensive Income and Accumulated Other Comprehensive Income
Comprehensive Income Note [Text Block]
Fair Value Disclosures [Abstract]
Fair Value Measurements
Fair Value Disclosures [Text Block]
License and Collaboration Agreements
Collaborative Arrangement Disclosure [Text Block]
License agreement.
License Agreements
License Agreements [Text Block]
Compensation And Retirement Disclosure [Abstract]
401(k) Profit Sharing Plan and Trust
Compensation And Employee Benefit Plans [Text Block]
Income Tax Disclosure [Abstract]
Income Taxes
Income Tax Disclosure [Text Block]
Commitments And Contingencies Disclosure [Abstract]
Commitments and Contingencies
Commitments And Contingencies Disclosure [Text Block]
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]
Equity Incentive Plans
Disclosure Of Compensation Related Costs Share Based Payments [Text Block]
Earnings Per Share [Abstract]
Net Loss per Common Share
Earnings Per Share [Text Block]
Related Party Transactions [Abstract]
Related Party Transaction
Related Party Transactions Disclosure [Text Block]
Quarterly Financial Information Disclosure [Abstract]
Selected Quarterly Financial Data (Unaudited)
Quarterly Financial Information [Text Block]
Subsequent Events [Abstract]
Subsequent Events
Subsequent Events [Text Block]
Basis of Presentation
Basis Of Accounting Policy Policy [Text Block]
Licensing and Collaboration Revenue
Revenue From Contract With Customer Policy [Text Block]
Offering costs.
Offering Costs
Offering Costs Policy [Text Block]
Segment Information
Segment Reporting Policy Policy [Text Block]
Use of Estimates
Use Of Estimates
Fair Value of Financial Instruments
Fair Value Of Financial Instruments Policy
Cash and Cash Equivalents
Cash And Cash Equivalents Policy [Text Block]
Foreign Currency
Foreign Currency Transactions And Translations Policy [Text Block]
Research and Development
Research And Development Expense Policy
Patents
Goodwill And Intangible Assets Intangible Assets Policy
Income Taxes
Income Tax Policy [Text Block]
Concentrations of Credit Risk
Concentration Risk Credit Risk
Net Loss per Share
Earnings Per Share Policy [Text Block]
Comprehensive Loss
Comprehensive Income Policy Policy [Text Block]
Recent Accounting Pronouncements
New Accounting Pronouncements Policy Policy [Text Block]
Summary of common stock reserved for future issuance.
Summary of Shares of Common Stock Reserved for Future Issuance
Summary Of Common Stock Reserved For Future Issuance Table [Text Block]
Schedule of Development Derivative Liability
Schedule Of Derivative Liabilities At Fair Value Table [Text Block]
Schedule of Accrued Expenses
Schedule Of Accrued Liabilities Table [Text Block]
Schedule of Additional Information Related to Operating Lease Assets and Liabilities
Lease Cost Table [Text Block]
Supplemental cash flow information related to operating leases.
Supplemental Cash Flow Information Related to Operating Leases
Supplemental Cash Flow Information Related To Operating Leases Table [Text Block]
Maturity of Operating Lease Liabilities
Lessee Operating Lease Liability Maturity Table [Text Block]
Schedule of Amortized Cost, Gross Unrealized Holding Losses and Fair Value of Available-for-Sale Debt Securities by Type of Security
Marketable Securities [Text Block]
Summary of Changes in Accumulated Other Comprehensive Income/(Loss), by Component
Schedule Of Accumulated Other Comprehensive Income Loss Table [Text Block]
Measurement Frequency
Fair Value By Measurement Frequency [Axis]
Measurement Frequency
Fair Value Measurement Frequency [Domain]
Fair Value, Nonrecurring [Member]
Fair Value Measurements Nonrecurring [Member]
Fair Value, Recurring [Member]
Fair Value Measurements Recurring [Member]
Schedule of Financial Instruments and the Related Fair Value Hierarchy of the Valuation Techniques Utilized
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Valuation Techniques Table [Text Block]
Components of Loss From Continuing Operation Before Provision for Income Taxes
Schedule Of Income Before Income Tax Domestic And Foreign Table [Text Block]
Schedule of Provision for Income Tax Expense
Schedule Of Components Of Income Tax Expense Benefit Table [Text Block]
Schedule of Effective Income Tax Rate Provision Amount Differs from Statutory U.S. Federal Income Tax Rate
Schedule Of Effective Income Tax Rate Reconciliation Table [Text Block]
Schedule of Deferred Tax Assets and Liabilities
Schedule Of Deferred Tax Assets And Liabilities Table [Text Block]
Summary of Share-based Compensation Expense
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Text Block]
Summary of Stock Option Activity
Schedule Of Share Based Compensation Stock Options Activity Table [Text Block]
Summary of Assumption Used to Estimate the Grant Date Fair Value
Schedule Of Share Based Payment Award Stock Options Valuation Assumptions Table [Text Block]
Schedule of Unvested Restricted Stock Units Activity
Schedule Of Nonvested Restricted Stock Units Activity Table [Text Block]
Summary of Basic and Diluted Net Loss per Common Share
Schedule Of Earnings Per Share Basic And Diluted Table [Text Block]
Summary of Shares Outstanding that were Excluded from Calculation of Diluted Net Loss Per Share
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Text Block]
Summary of Interim Financial Information on Quarterly Basis
Schedule Of Quarterly Financial Information Table [Text Block]
Aggregate milestone payments upon achievement of specified one-time regulatory and commercial milestone events.
Development cost reimbursement.
Royalties entitled to receive after first commercial sale of applicable licensed product period.
Upfront payment.
Nature of organization and operations.
Nature of organization and operations.
Nature Of Organization And Operations [Table]
Nature Of Organization And Operations [Table]
Collaborative Arrangement and Arrangement Other than Collaborative
Type Of Arrangement [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Arrangements And Nonarrangement Transactions [Member]
Collaboration and license agreement.
Collaboration and License Agreement [Member]
Collaboration And License Agreement [Member]
Counterparty Name
Counterparty Name [Axis]
Counterparty Name
Repurchase Agreement Counterparty Name [Domain]
Swedish Orphan Biovitrum AB (Publ).
Swedish Orphan Biovitrum AB (Publ) [Member]
Swedish Orphan Biovitrum A B Publ [Member]
Statistical Measurement
Range [Axis]
Statistical Measurement
Range [Member]
Maximum [Member]
Maximum [Member]
Minimum [Member]
Minimum [Member]
Long-term Debt, Type
Longterm Debt Type [Axis]
Long-term Debt, Type
Longterm Debt Type [Domain]
Convertible senior notes one due two thousand twenty six.
Convertible Senior Notes Due 2026 [Member]
Convertible Senior Notes One Due Two Thousand Twenty Six [Member]
Sale of Stock
Subsidiary Sale Of Stock [Axis]
Sale of Stock
Sale Of Stock Name Of Transaction [Domain]
Private Offering [Member]
Private Placement [Member]
Debt Instrument
Debt Instrument [Axis]
Debt Instrument, Name
Debt Instrument Name [Domain]
2020 Convertible notes.
2020 Convertible Notes [Member]
Two Thousand Twenty Convertible Notes [Member]
2019 Convertible notes.
2019 Convertible Notes [Member]
Two Thousand Nineteen Convertible Notes [Member]
Convertible senior notes due two thousand twenty six.
Convertible Senior Notes Due 2026 [Member]
Convertible Senior Notes Due Two Thousand Twenty Six [Member]
Subsequent Event Type
Subsequent Event Type [Axis]
Subsequent Event Type
Subsequent Event Type [Domain]
Subsequent Event [Member]
Subsequent Event [Member]
Exchange agreements.
Exchange Agreements [Member]
Exchange Agreements [Member]
Capped call transaction.
Capped Call Transactions [Member]
Capped Call Transaction [Member]
Follow on public offerings.
Follow-on Public Offerings [Member]
Follow On Public Offerings [Member]
Over Allotment Option [Member]
Over Allotment Option [Member]
Nature Of Organization And Operations [Line Items]
Nature Of Organization And Operations [Line Items]
Upfront Payment
Upfront Payment
Aggregate milestone payments upon achievement of specified one-time regulatory and commercial milestone events
Aggregate Milestone Payments Upon Achievement Of Specified One Time Regulatory And Commercial Milestone Events
Development cost reimbursement
Development Cost Reimbursement
Royalties entitled to receive after first commercial sale of applicable licensed product period
Royalties Entitled To Receive After First Commercial Sale Of Applicable Licensed Product Period
Debt instrument maturity year.
Payments to acquire convertible debt.
Principal amount
Debt Instrument Face Amount
Debt instrument, stated percentage
Debt Instrument Interest Rate Stated Percentage
Debt instrument maturity year
Debt Instrument Maturity Year
Purchase price of convertible notes
Payments To Acquire Convertible Debt
Net proceeds from the sale of the notes
Proceeds From Convertible Debt
Payments of transactions cost
Payments Of Debt Issuance Costs
Debt instrument, due and payment description
Debt Instrument Payment Terms
Debt instrument, frequency of periodic payment
Debt Instrument Frequency Of Periodic Payment
Maturity date
Debt Instrument Maturity Date
Aggregate principal amount converted
Debt Conversion Converted Instrument Amount1
Aggregate principal amount converted into shares
Debt Conversion Converted Instrument Shares Issued1
Debt instrument number of counterparties.
Debt Instrument, convertible, initial conversion price.
Number of counterparties
Debt Instrument Number Of Counterparties
Initial conversion price
Debt Instrument Convertible Initial Conversion Price
Issuance of common stock in follow-on offering, shares
Price of common stock
Shares Issued Price Per Share
Proceeds from follow-on public offering after deducting underwriting discounts and commissions
Underwriting discounts and commissions
Payments For Underwriting Expense
Offering Cost
Deferred Offering Costs
Cash and cash equivalents and marketable securities.
Cash and cash equivalents and marketable securities
Cash And Cash Equivalents And Marketable Securities
Schedule of summary of significant accounting policies.
Schedule of summary of significant accounting policies.
Schedule Of Summary Of Significant Accounting Policies [Table]
Schedule Of Summary Of Significant Accounting Policies [Table]
Accounting Standards Update
Adjustments For New Accounting Pronouncements [Axis]
Accounting Standards Update
Type Of Adoption [Member]
Accounting Standards Update 2020 06.
ASU 2020-06 [Member]
Accounting Standards Update202006 [Member]
Schedule Of Summary Of Significant Accounting Policies [Line Items]
Schedule Of Summary Of Significant Accounting Policies [Line Items]
Number of operating segment
Number Of Operating Segments
Change in accounting principle accounting standards update adopted
Change In Accounting Principle Accounting Standards Update Adopted
Change in accounting principle accounting standards update adoption date
Change In Accounting Principle Accounting Standards Update Adoption Date
Schedule Of Stock By Class [Table]
Schedule Of Stock By Class [Table]
Plan Name
Plan Name [Axis]
Plan Name
Plan Name [Domain]
Two thousand ten stock incentive plan.
2010 Stock Incentive Plan [Member]
Two Thousand Ten Stock Incentive Plan [Member]
Two thousand seventeen stock incentive plan.
2017 Stock Incentive Plan [Member]
Two Thousand Seventeen Stock Incentive Plan [Member]
Two thousand seventeen employee stock purchase plan.
2017 Employee Stock Purchase Plan [Member]
Two Thousand Seventeen Employee Stock Purchase Plan [Member]
Class Of Stock [Line Items]
Class Of Stock [Line Items]
Common stock reserved for future issuance
Common Stock Capital Shares Reserved For Future Issuance
Common stock warrants
Debt Conversion Converted Instrument Warrants Or Options Issued1
Additional funding amount upon achievement of development milestones.
Number of milestone payments.
Development funding for minimum period of operating expense
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table]
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table]
SFJ agreement [member].
SFJ Agreement [Member]
S F J Agreement [Member]
Regulatory Agency
Regulatory Agency [Axis]
Regulatory Agency
Regulatory Agency [Domain]
US food and drug administration and european medicines agency.
Regulatory Approval Granted by FDA and EMA [Member]
U S Food And Drug Administration And European Medicines Agency [Member]
Fair Value Hierarchy and NAV
Fair Value By Fair Value Hierarchy Level [Axis]
Fair Value Hierarchy and NAV
Fair Value Measurements Fair Value Hierarchy [Domain]
Level 3 [Member]
Fair Value Inputs Level3 [Member]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Proceeds from SFJ agreement
Proceeds From Collaborators
Additional funding amount upon achievement of development milestones
Additional Funding Amount Upon Achievement Of Development Milestones
Number of milestone payments
Number Of Milestone Payments
Development funding for minimum period of operating expense
Development Funding For Minimum Period Of Operating Expense
Increase in additional funding for development costs.
Increase in additional funding for development costs
Increase In Additional Funding For Development Costs
Number of additional annual payments.
Aggregate amount of additional annual payments.
Obligated to pay initial payment
Contractual Obligation
Aggregate amount of additional annual payments
Aggregate Amount Of Additional Annual Payments
Number of additional annual payments
Number Of Additional Annual Payments
Proceeds from collaborators of additional milestones.
Proceeds from collaborators of additional milestones
Proceeds From Collaborators Of Additional Milestones
Development derivative liabilities gross.
Minimum payment of additional funding amount.
Balance at fair market value
Development Derivative Liabilities Gross
Amounts received under the SFJ agreement and SFJ amendment
Minimum Payment Of Additional Funding Amount
Loss recorded in loss from remeasurement of development derivative liability
Balance at fair market value
Implied cost of borrowing discount rates.
Implied cost of borrowing discount rates
Implied Cost Of Borrowing Discount Rates
Accrued research and development current.
Accrued license fees, current.
Accrued payroll liabilities.
Accrued research and development
Accrued Research And Development Current
Accrued license fee
Accrued License Fees Current
Accrued payroll liabilities
Accrued Payroll Liabilities Current
Other
Other Accrued Liabilities Current
Total
Prepaid research and development cost current.
Prepaid research and development
Prepaid Research And Development Cost Current
Debt Instrument [Table]
Debt Instrument [Table]
Liability component.
Liability Component [Member]
Liability Component [Member]
Equity component.
Equity Component [Member]
Equity Component [Member]
Loan and security agreement.
Loan and Security Agreement [Member]
Loan And Security Agreement [Member]
Lender Name
Line Of Credit Facility [Axis]
Line of Credit Facility, Lender
Line Of Credit Facility Lender [Domain]
Silicon valley bank.
Silicon Valley Bank [Member]
Silicon Valley Bank [Member]
Variable Rate
Variable Rate [Axis]
Variable Rate
Variable Rate [Domain]
Prime Rate [Member]
Prime Rate [Member]
Class of Stock
Statement Class Of Stock [Axis]
Class of Stock
Class Of Stock [Domain]
Convertible Preferred Stock [Member]
Convertible Preferred Stock [Member]
Credit Facility
Credit Facility [Axis]
Credit Facility
Credit Facility [Domain]
Term loan facility.
Term Loan Facility [Member]
Term Loan Facility [Member]
Unsecured promissory note.
Unsecured Promissory Note [Member]
Unsecured Promissory Note [Member]
Related Party
Related Party Transactions By Related Party [Axis]
Related Party
Related Party [Domain]
Golda Darty Partners S A.
Golda Darty Partners S.A. [Member]
Golda Darty Partners S A [Member]
Debt Instrument [Line Items]
Debt Instrument [Line Items]
Payment of convertible debt discounts and commissions.
Payment of convertible debt offering expenses.
Payment of convertible debt discounts and commissions
Payment Of Convertible Debt Discounts And Commissions
Payment of convertible debt offering expenses
Payment Of Convertible Debt Offering Expenses
Terms of conversion
Debt Instrument Convertible Terms Of Conversion Feature
Conversion ratio
Debt Instrument Convertible Conversion Ratio1
Conversion price
Debt Instrument Convertible Conversion Price1
Redemption period, start date
Debt Instrument Redemption Period Start Date
Threshold percentage of stock price trigger
Debt Instrument Convertible Threshold Percentage Of Stock Price Trigger
Threshold trading days
Debt Instrument Convertible Threshold Trading Days
Threshold consecutive trading days
Debt Instrument Convertible Threshold Consecutive Trading Days1
Redemption price, percentage
Debt Instrument Redemption Price Percentage
Debt instrument convertible carrying amount of liability component.
Debt instrument effective interest rate
Debt Instrument Interest Rate Effective Percentage
Debt instrument convertible carrying amount of liability component
Debt Instrument Convertible Carrying Amount Of Liability Component
Debt discount
Debt Instrument Unamortized Discount
Debt issuance costs
Deferred Finance Costs Net
Debt interest expense
Interest Expense Debt
Accrued semi annual coupon payable
Interest Expense Debt Excluding Amortization
Amortization of debt issuance costs
Amortization Of Financing Costs
Debt issuance costs gross
Deferred Finance Costs Gross
Long-term debt
Long Term Debt
Debt Instrument, convertible, initial conversion cap price.
Initial cap price
Debt Instrument Convertible Initial Conversion Cap Price
Sale price
Share Price
Premium paid for capped call transaction.
Premium paid for capped call transactions
Premium Paid For Capped Call Transaction
Debt instrument number of equal monthly installments.
Term loan facility
Secured Debt
Interest bear rate
Debt Instrument Basis Spread On Variable Rate1
Debt instrument, number of equal monthly installments
Debt Instrument Number Of Equal Monthly Installments
Debt instrument per diem interest amount.
Final payment percentage equal to original principal amount.
Final payment due amount
Debt Instrument Carrying Amount
Debt instrument per diem interest amount
Debt Instrument Per Diem Interest Amount
Final payment percentage equal to original principal amount
Final Payment Percentage Equal To Original Principal Amount
Final payment towards original principal amount
Repayments Of Senior Debt
Prepayment fee
Payments Of Debt Extinguishment Costs
Loss on extinguishment of debt
Class of warrant or right expiration term.
Warrant to purchase common stock
Exercise price per share
Class Of Warrant Or Right Exercise Price Of Warrants Or Rights1
Warrant term
Class Of Warrant Or Right Expiration Term
Aggregate purchase price
Payments For Repurchase Of Warrants
Debt instrument accrued interest rate.
Accrued interest rate
Debt Instrument Accrued Interest Rate
Repayment of related party due amount including diem interest
Repayments Of Related Party Debt
Fair value of warrant
Warrants And Rights Outstanding
Additional operating lease right of use asset.
Additional operating lease liability.
Lessee Lease Description [Table]
Lessee Lease Description [Table]
ASU 2016-02 [Member]
Accounting Standards Update201602 [Member]
Lessee Lease Description [Line Items]
Lessee Lease Description [Line Items]
Operating lease asset
Operating lease liability
Operating Lease Liability
Additional operating lease asset
Additional Operating Lease Right Of Use Asset
Additional operating lease liability
Additional Operating Lease Liability
Lessee operating lease maximum term of options to terminate lease.
Operating lease description
Lessee Operating Lease Description
Operating lease, term of contract
Lessee Operating Lease Term Of Contract
Operating lease options to extend lease
Lessee Operating Lease Renewal Term
Operating lease, existence of option to extend
Lessee Operating Lease Existence Of Option To Extend
Operating lease maximum term of options to terminate lease
Lessee Operating Lease Maximum Term Of Options To Terminate Lease
Operating lease assets
Operating lease liabilities
Weighted average remaining term in years
Operating Lease Weighted Average Remaining Lease Term1
Weighted average discount rate used to measure outstanding lease liabilities
Operating Lease Weighted Average Discount Rate Percent
Operating lease expense
Operating Lease Cost
Operating cash flows from operating leases
Operating Lease Payments
Operating lease assets obtained in exchange for lease obligations
Right Of Use Asset Obtained In Exchange For Operating Lease Liability
2021
Lessee Operating Lease Liability Payments Due Next Twelve Months
2022
Lessee Operating Lease Liability Payments Due Year Two
2023
Lessee Operating Lease Liability Payments Due Year Three
2024
Lessee Operating Lease Liability Payments Due Year Four
2025 and thereafter
Lessee Operating Lease Liability Payments Due Year Five And Thereafter
Total future minimum lease payments
Lessee Operating Lease Liability Payments Due
Less imputed interest
Lessee Operating Lease Liability Undiscounted Excess Amount
Marketable Securities [Table]
Marketable Securities [Table]
Financial Instrument
Financial Instrument [Axis]
Financial Instruments
Transfers And Servicing Of Financial Instruments Types Of Financial Instruments [Domain]
U.S. Government-Related Obligations [Member]
U S Government Agencies Debt Securities [Member]
Marketable Securities [Line Items]
Marketable Securities [Line Items]
Available for sale securities:
Available For Sale Securities [Abstract]
Amortized Cost
Available For Sale Debt Securities Amortized Cost Basis
Gross Unrealized Holding Gains
Available For Sale Debt Securities Accumulated Gross Unrealized Gain Before Tax
Gross Unrealized Holding Losses
Available For Sale Debt Securities Accumulated Gross Unrealized Loss Before Tax
Fair Value
Available For Sale Securities Debt Securities
Available-for-sale securities
Accumulated Other Comprehensive Income Loss [Table]
Accumulated Other Comprehensive Income Loss [Table]
Unrealized Gains (Losses) from Marketable Securities [Member]
Accumulated Net Unrealized Investment Gain Loss [Member]
Foreign Currency Translation Adjustment [Member]
Accumulated Translation Adjustment [Member]
Total Accumulated Other Comprehensive Income (Loss) [Member]
Accumulated Other Comprehensive Income Loss [Line Items]
Accumulated Other Comprehensive Income Loss [Line Items]
Net other comprehensive income (loss)
Other Comprehensive Income Loss Net Of Tax
Fair Value By Balance Sheet Grouping [Table]
Fair Value By Balance Sheet Grouping [Table]
Level 1 [Member]
Fair Value Inputs Level1 [Member]
Level 2 [Member]
Fair Value Inputs Level2 [Member]
Asset Class
Fair Value By Asset Class [Axis]
Asset Class
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation By Asset Class [Domain]
Bank Certificates of Deposit [Member]
Certificates Of Deposit [Member]
Money Market Funds [Member]
Money Market Funds [Member]
Fair Value Balance Sheet Grouping Financial Statement Captions [Line Items]
Fair Value Balance Sheet Grouping Financial Statement Captions [Line Items]
Total Financial Assets
Assets Fair Value Disclosure
Convertible senior notes.
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Liability Class
Fair Value By Liability Class [Axis]
Fair Value by Liability Class
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation By Liability Class [Domain]
Convertible senior notes.
Convertible Senior Notes [Member]
Convertible Senior Notes [Member]
Development derivative liability under financial liability.
Development Derivative Liability [Member]
Development Derivative Liability [Member]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Convertible notes
Convertible Senior Notes Noncurrent
Convertible notes, interest rate
Cash and Cash Equivalents [Member]
Cash And Cash Equivalents [Member]
Marketable securities.
Marketable Securities [Member]
Marketable Securities [Member]
US Government Obligations [Member]
Total Financial Liabilities
Financial Liabilities Fair Value Disclosure
Change in fair value of derivative liability, percentage.
Percentage of cost of borrowing
Derivative liability measurement input
Derivative Liability Measurement Input
Change in fair value of derivative liability, percentage
Change In Fair Value Of Derivative Liability Percentage
Change in fair value of derivative liability
Liabilities Fair Value Adjustment
ASC Topic 808
Accounting Standards Update201818 [Member]
non-refundable upfront payment.
Non-refundable Upfront Payment
Non Refundable Upfront Payment
Contra research and development expense.
Contra research and development current.
Contra research and development long-term assets.
Contra research and development expense
Contra Research And Development Expense
Contra research and development current
Contra Research And Development Current
Contra research and development long-term assets
Contra Research And Development Long Term Assets
Annual license maintenance fees.
Sales milestone payments based on achievement of annual sales milestones.
University of pennsylvania.
University of Pennsylvania [Member]
University Of Pennsylvania [Member]
Two thousand ten license agreement.
2010 License Agreement [Member]
Two Thousand Ten License Agreement [Member]
Sobi agreement and another licensing transaction.
Sobi Agreement and Another Licensing Transaction [Member]
Sobi Agreement And Another Licensing Transaction [Member]
Annual maintenance fees
Annual License Maintenance Fees
Aggregate milestones payments
Milestone payments based on annual sales milestones
Sales Milestone Payments Based On Achievement Of Annual Sales Milestones
Number of licensed products.
Royalty expense owed.
Future milestone payments.
Percentage of royalty fees payments.
Milestone payments.
Number of licensed products
Number Of Licensed Products
Annual milestone payment made
Milestone Payments
Royalty expense owed
Royalty Expense Owed
Future milestone payments
Future Milestone Payments
Payment of royalty fees
Percentage Of Royalty Fees Payments
Defined contribution plan eligibility criteria minimum age of full time employees.
Defined Contribution Plan, Plan Name [Extensible List]
Defined Contribution Plan Plan Name Extensible List
Minimum age of full-time employees eligible to participate in the plan
Defined Contribution Plan Eligibility Criteria Minimum Age Of Full Time Employees
Employer contributions made to the 401(k) Plan
Defined Contribution Plan Cost Recognized
Components Of Income Tax Expense Benefit Continuing Operations [Abstract]
Domestic
Income Loss From Continuing Operations Before Income Taxes Domestic
Foreign
Income Loss From Continuing Operations Before Income Taxes Foreign
Total
Income Loss From Continuing Operations Before Income Taxes Minority Interest And Income Loss From Equity Method Investments
Income Tax Expense Benefit Continuing Operations [Abstract]
Current income tax expense:
Current Federal State And Local Tax Expense Benefit [Abstract]
U.S. Federal
Current Federal Tax Expense Benefit
U.S. State and Local
Current State And Local Tax Expense Benefit
Foreign
Current Foreign Tax Expense Benefit
Total current income tax expense
Current Income Tax Expense Benefit
Deferred income tax expense:
Deferred Federal State And Local Tax Expense Benefit [Abstract]
U.S. Federal
Deferred Federal Income Tax Expense Benefit
U.S. State and Local
Deferred State And Local Income Tax Expense Benefit
Foreign
Deferred Federal State And Local Tax Expense Benefit
Total deferred income tax expense
Deferred Income Tax Expense Benefit
Total tax expense
Income taxes.
Income taxes.
Income Taxes [Table]
Income Taxes [Table]
Income Tax Authority
Income Tax Authority [Axis]
Income Tax Authority
Income Tax Authority [Domain]
Federal [Member]
Domestic Country [Member]
State [Member]
State And Local Jurisdiction [Member]
Foreign [Member]
Foreign Country [Member]
Income Taxes [Line Items]
Income Taxes [Line Items]
Current income tax expense or benefit
Deferred income tax expense or benefit
Statutory U.S. federal income tax, Amount
Income Tax Reconciliation Income Tax Expense Benefit At Federal Statutory Income Tax Rate
Foreign tax rate differential
Income Tax Reconciliation Foreign Income Tax Rate Differential
State income taxes, net of federal benefit, Amount
Income Tax Reconciliation State And Local Income Taxes
Change in valuation allowances, Amount
Income Tax Reconciliation Change In Deferred Tax Assets Valuation Allowance
Intellectual property transfer
Income Tax Reconciliation Intellectual Property Transfer
Tax credits, Amount
Income Tax Reconciliation Tax Credits
Change in state apportionment, Kentucky tax reform and other, Amount
Tax Cuts And Jobs Act Of2017 Change In State Apportionment Tax Reform And Other
Permanent and other including share based payments excess deductions
Income Tax Reconciliation Permanent And Other Including Share Based Payments Excess Deductions
Effective income tax rate reconciliation intellectual property transfer.
Effective income tax rate reconciliation change in state apportionment tax reform and other.
Effective income tax rate change in permanent and other.
Statutory U.S. federal income tax, Percentage of income before income taxes
Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate
Foreign tax rate differential
Effective Income Tax Rate Reconciliation Tax Settlements Foreign
State income taxes, net of federal benefit, Percentage of income before income taxes
Effective Income Tax Rate Reconciliation State And Local Income Taxes
Change in valuation allowances, Percentage of income before income taxes
Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance
Intellectual property transfer
Effective Income Tax Rate Reconciliation Intellectual Property Transfer
Tax credits, Percentage of income before income taxes
Effective Income Tax Rate Reconciliation Tax Credits
Change in state apportionment, Kentucky tax reform and other, Percentage of income before income taxes
Effective Income Tax Rate Reconciliation Change In State Apportionment Tax Reform And Other
Permanent and other including share based payments excess deductions
Effective Income Tax Rate Change In Permanent And Other
Effective income tax provision, Percentage of income before income taxes
Effective Income Tax Rate Continuing Operations
Net impact on effective tax rate
Income Tax Reconciliation Change In Enacted Tax Rate
Deferred tax assets deferred interest expense.
Deferred tax assets contribution carryforwards.
Deferred tax assets orphan drug credits.
Deferred tax liability section 481 (a) adjustment.
Net deferred tax assets before valuation allowance.
Components Of Deferred Tax Assets And Liabilities [Abstract]
Deferred tax assets:
Deferred Tax Assets Gross [Abstract]
Intangible assets
Deferred Tax Assets Goodwill And Intangible Assets
Share-based compensation
Deferred Tax Assets Tax Deferred Expense Compensation And Benefits Share Based Compensation Cost
Deferred interest expense
Deferred Tax Assets Deferred Interest Expense
Contribution carryforwards
Deferred Tax Assets Contribution Carryforwards
Net operating loss carryforwards
Deferred Tax Assets Operating Loss Carryforwards
Research and development credits
Deferred Tax Assets Tax Credit Carryforwards Research
Orphan drug credits
Deferred Tax Assets Orphan Drug Credits
Development derivative liability
Deferred Tax Assets Derivative Instruments
Accruals
Deferred Tax Assets Tax Deferred Expense Reserves And Accruals
Other
Deferred Tax Assets Other
Total deferred tax assets
Deferred Tax Assets Gross
Deferred tax liabilities:
Deferred Tax Liabilities [Abstract]
Fixed assets
Deferred Tax Liabilities Property Plant And Equipment
Convertible debt
Deferred Tax Liabilities Financing Arrangements
481(a) adjustment
Deferred Tax Liabilities Section481 A Adjustment
Total deferred tax liabilities
Deferred Income Tax Liabilities
Net deferred tax assets before allowance:
Net Deferred Tax Assets Before Valuation Allowance
Less valuation allowance
Deferred Tax Assets Valuation Allowance
Net deferred tax assets
Deferred Tax Assets Liabilities Net
Deferred tax asset, increase in valuation allowance
Valuation Allowance Deferred Tax Asset Change In Amount
Deferred tax assets tax credit carryforwards research and development.
Net operating loss carryforward expiration year.
Research and development tax credit carryforward expiration year.
Net operating loss carryforwards
Operating Loss Carryforwards
Research and development tax credit carryforwards
Deferred Tax Assets Tax Credit Carryforwards Research And Development
Net operating loss carryforward indefinitely
Deferred Tax Assets Operating Loss Carryforwards Not Subject To Expiration
Net operating loss carryforward expiration year
Net Operating Loss Carryforward Expiration Year
Research and development tax credit carryforward expiration year
Research And Development Tax Credit Carryforward Expiration Year
Net operating loss carryforward period.
Net operating loss carryforward period
Net Operating Loss Carryforward Period
Cumulative changes in ownership interest of significant stockholders
Equity Method Investment Ownership Percentage
Interest and penalties
Unrecognized Tax Benefits Income Tax Penalties And Interest Expense
Accrued for interest and penalties
Unrecognized Tax Benefits Income Tax Penalties And Interest Accrued
Income tax examination description
Income Tax Examination Description
Operating lease area.
Monthly lease payment.
Lease commencement date.
Percentage increase to existing per month rent payment.
Operating lease square feet of office space leased.
Commitments and contingencies.
Commitments And Contingencies [Table]
Commitments And Contingencies [Table]
Commitments And Contingencies [Table]
Geographical
Statement Geographical [Axis]
Geographical
Segment Geographical [Domain]
Waltham, Massachusetts.
Waltham, Massachusetts [Member]
Waltham Massachusetts [Member]
Amended waltham office space lease.
Amended Waltham Office Space Lease [Member]
Amended Waltham Office Space Lease [Member]
Commitments And Contingencies [Line Items]
Commitments And Contingencies [Line Items]
Lease expiration date
Lease Expiration Date1
Area of operating lease
Operating Lease Area
Total leased square feet of office space
Operating Lease Square Feet Of Office Space Leased
Initial monthly lease payments per month
Monthly Lease Payment
Percentage increase to existing per month rent payment
Percentage Increase To Existing Per Month Rent Payment
Base rent payable
Lease commencement date
Lease Commencement Date
Incurred any cost to defend lawsuits or settle claims
Litigation Settlement Amount Awarded To Other Party
Estimated termination costs and other fees.
Estimated termination costs and other fees
Estimated Termination Costs And Other Fees
Non-cancellable purchase commitments
Long Term Purchase Commitment Amount
Share based compensation arrangement by share based payment award exercise price fair value of common stock percent.
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Equity incentive plan two thousand and ten.
Equity Incentive Plan 2010 [Member]
Equity Incentive Plan Two Thousand And Ten [Member]
Two thousand twenty inducement stock incentive plan.
2020 Inducement Stock Incentive Plan [Member]
Two Thousand Twenty Inducement Stock Incentive Plan [Member]
Twenty seventeen employee stock purchase plan.
2017 Employee Stock Purchase Plan [Member]
Twenty Seventeen Employee Stock Purchase Plan [Member]
Vesting
Vesting [Axis]
Vesting
Vesting [Domain]
Frist Anniversary [Member]
Share Based Compensation Award Tranche One [Member]
Second Anniversary [Member]
Share Based Compensation Award Tranche Two [Member]
Third Anniversary [Member]
Share Based Compensation Award Tranche Three [Member]
Share based compensation award tranche four.
Fourth Anniversary [Member]
Share Based Compensation Award Tranche Four [Member]
Award Type
Award Type [Axis]
Award Type
Share Based Compensation Arrangements By Share Based Payment Award Award Type And Plan Name [Domain]
Restricted Stock Units [Member]
Restricted Stock Units R S U [Member]
Employee stock purchase plan.
Employee Stock Purchase Plan [Member]
Employee Stock Purchase Plan [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Common stock shares reserved for issuance
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Authorized
Percentage of estimated fair value per share of common stock on the date of grant
Share Based Compensation Arrangement By Share Based Payment Award Exercise Price Fair Value Of Common Stock Percent
Percentage of voting shares
Share Based Compensation Arrangement By Share Based Payment Award Percentage Of Outstanding Stock Maximum
Percentage price of each share of the fair value on date of grant
Sharebased Compensation Arrangement By Sharebased Payment Award Purchase Price Of Common Stock Percent
Options expire from issuance date
Sharebased Compensation Arrangement By Sharebased Payment Award Expiration Period
Common stock issuance description.
Number of shares available for future grant
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant
Shares issuable increased during the period
Share Based Compensation Arrangement By Share Based Payment Award Number Of Additional Shares Authorized
Common Stock Issuance Description
Common Stock Issuance Description
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Abstract]
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Abstract]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Income Statement Location
Income Statement Location [Axis]
Income Statement Location
Income Statement Location [Domain]
Research and Development [Member]
Research And Development Expense [Member]
General and Administrative [Member]
General And Administrative Expense [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Share-based compensation expense
Allocated Share Based Compensation Expense
Stock options vesting period
Share Based Compensation Arrangement By Share Based Payment Award Award Vesting Period1
Stock options vesting description
Share Based Compensation Arrangement By Share Based Payment Award Award Vesting Rights
Stock options vesting percentage
Sharebased Compensation Arrangement By Sharebased Payment Award Award Vesting Rights Percentage
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Roll Forward
Shares Outstanding, Beginning balance
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Number
Shares, Granted
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Gross
Shares, Exercised
Shares, Forfeited
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures In Period
Shares Outstanding, Ending balance
Shares, Options exercisable
Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Number
Shares, Expected to vest
Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Outstanding Number
Weighted -Average Exercise Price Per Share Outstanding, Beginning balance
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price
Weighted -Average Exercise Price Per Share, Granted
Share Based Compensation Arrangements By Share Based Payment Award Options Grants In Period Weighted Average Exercise Price
Weighted -Average Exercise Price Per Share, Exercised
Share Based Compensation Arrangements By Share Based Payment Award Options Exercises In Period Weighted Average Exercise Price
Weighted -Average Exercise Price Per Share, Forfeited
Share Based Compensation Arrangements By Share Based Payment Award Options Forfeitures In Period Weighted Average Exercise Price
Weighted -Average Exercise Price Per Share, Outstanding, Ending balance
Weighted -Average Exercise Price Per Share, Options exercisable
Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Weighted Average Exercise Price
Weighted -Average Exercise Price Per Share, Expected to vest
Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Outstanding Weighted Average Exercise Price
Share based compensation arrangement by share based payment award options exercised in period weighted average grant date fair value.
Share based compensation arrangement by share based payment award options forfeited in period weighted average grant date fair value.
Share based compensation arrangement by share based payment award options exercisable weighted average grant date fair value.
Share based compensation arrangement by share based payment award options vested and expected to vest outstanding weighted average grant date fair value.
Weighted - Average Grant Date Fair Value Per Option Outstanding, Beginning balance
Sharebased Compensation Arrangement By Sharebased Payment Award Options Nonvested Weighted Average Grant Date Fair Value
Weighted - Average Grant Date Fair Value Per Option, Granted
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Weighted Average Grant Date Fair Value
Weighted - Average Grant Date Fair Value Per Option, Exercised
Share Based Compensation Arrangement By Share Based Payment Award Options Exercised In Period Weighted Average Grant Date Fair Value
Weighted - Average Grant Date Fair Value Per Option, Forfeited
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeited In Period Weighted Average Grant Date Fair Value
Weighted - Average Grant Date Fair Value Per Option Outstanding, Ending balance
Weighted - Average Grant Date Fair Value Per Option, Options exercisable
Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Weighted Average Grant Date Fair Value
Weighted - Average Grant Date Fair Value Per Option, Expected to vest
Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Outstanding Weighted Average Grant Date Fair Value
Share based compensation arrangement by share based payment award options grant in period weighted average remaining contractual term.
Share based compensation arrangement by share based payment award options exercised in period weighted average remaining contractual term.
Share based compensation arrangement by share based payment award options forefeited in period weighted average remaining contractual term.
Weighted - Average Contractual Life Outstanding, Balance
Sharebased Compensation Arrangement By Sharebased Payment Award Options Outstanding Weighted Average Remaining Contractual Term2
Weighted - Average Contractual Life, Granted
Share Based Compensation Arrangement By Share Based Payment Award Options Grant In Period Weighted Average Remaining Contractual Term
Weighted - Average Contractual Life, Exercised
Share Based Compensation Arrangement By Share Based Payment Award Options Exercised In Period Weighted Average Remaining Contractual Term
Weighted - Average Contractual Life, Forfeited
Share Based Compensation Arrangement By Share Based Payment Award Options Forefeited In Period Weighted Average Remaining Contractual Term
Weighted - Average Contractual Life, Options exercisable
Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Weighted Average Remaining Contractual Term1
Weighted - Average Contractual Life, Expected to vest
Sharebased Compensation Arrangement By Sharebased Payment Award Options Vested And Expected To Vest Outstanding Weighted Average Remaining Contractual Term1
Share based compensation arrangement by share based payment award options grant in period intrinsic value.
Share based compensation arrangement by share based payment award options forfeited in period intrinsic value.
Aggregate Intrinsic Value, Outstanding
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Intrinsic Value
Aggregate Intrinsic Value, Granted
Share Based Compensation Arrangement By Share Based Payment Award Options Grant In Period Intrinsic Value
Aggregate Intrinsic Value, Exercised
Share Based Compensation Arrangement By Share Based Payment Award Options Exercises In Period Total Intrinsic Value
Aggregate Intrinsic Value, Forfeited
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeited In Period Intrinsic Value
Aggregate Intrinsic Value, Options exercisable
Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Intrinsic Value1
Aggregate Intrinsic Value, Expected to vest
Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Outstanding Aggregate Intrinsic Value
Aggregate number of stock options granted to purchase common stock
Share based compensation arrangement by share based payment award options exercised in period aggregate intrinsic value.
Aggregate intrinsic value of options exercised in period
Share Based Compensation Arrangement By Share Based Payment Award Options Exercised In Period Aggregate Intrinsic Value
Fair market value of options vested in period
Sharebased Compensation Arrangement By Sharebased Payment Award Options Vested In Period Fair Value1
Unrecognized compensation expense
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Stock Options
Estimated weighted-average period to recognize
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Period For Recognition1
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions and Methodology [Abstract]
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions And Methodology [Abstract]
Risk-free interest rate, minimum
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Risk Free Interest Rate Minimum
Risk-free interest rate, maximum
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Risk Free Interest Rate Maximum
Risk-free interest rate
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Risk Free Interest Rate
Dividend yield
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Dividend Rate
Volatility
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Volatility Rate
Volatility, minimum
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Volatility Rate Minimum
Volatility, maximum
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Volatility Rate Maximum
Expected terms (years)
Sharebased Compensation Arrangement By Sharebased Payment Award Fair Value Assumptions Expected Term1
Number of Stock Units
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Roll Forward
Unvested Beginning Balance
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Number
Granted
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period
Vested
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period
Forfeited
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Forfeited In Period
Unvested Ending Balance
Weighted Average Grant Date Fair Value Per Share
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Weighted Average Grant Date Fair Value Roll Forward
Unvested Balance at December 31, 2019
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Weighted Average Grant Date Fair Value
Granted
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period Weighted Average Grant Date Fair Value
Vested
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period Weighted Average Grant Date Fair Value
Forfeited
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Forfeitures Weighted Average Grant Date Fair Value
Unvested Balance at December 31, 2020
Percentage of earnings withheld to purchase shares of common stock.
Cash received from issuance of purchase rights.
Share based compensation arrangement by share based payment award percentage of earnings withheld to participate in an offering.
Percentage of earnings withheld to participate in offering
Sharebased Compensation Arrangement By Share Based Payment Award Percentage Of Earnings Withheld To Participate In An Offering
Percentage of earnings withheld to purchase shares of common stock
Percentage Of Earnings Withheld To Purchase Shares Of Common Stock
Common stock issued at average per share price
Cash received from issuance of purchase rights
Cash Received From Issuance Of Purchase Rights
Numerator:
Net Income Loss [Abstract]
Net loss
Denominator:
Weighted Average Number Of Shares Outstanding [Abstract]
Weighted-average number of common shares used in net loss per common share -- basic and diluted
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Abstract]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Abstract]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Antidilutive Securities
Antidilutive Securities Excluded From Computation Of Earnings Per Share By Antidilutive Securities [Axis]
Antidilutive Securities, Name
Antidilutive Securities Name [Domain]
Convertible notes.
Convertible Notes [Member]
Convertible Notes [Member]
Common Stock Under Option [Member]
Employee Stock Option [Member]
Common stock warrants.
Common Stock Warrants [Member]
Common Stock Warrants [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share, amount
Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount
Payable on exclusive license option thereafter.
Software development service costs.
Schedule Of Related Party Transactions By Related Party [Table]
Schedule Of Related Party Transactions By Related Party [Table]
Revon systems, Inc.
Revon [Member]
Revon Systems Inc [Member]
Related Party Transaction
Related Party Transaction [Axis]
Related Party Transaction
Related Party Transaction [Domain]
License agreement and services agreement.
License Agreement and Services Agreement [Member]
License Agreement And Services Agreement [Member]
Related Party Transaction [Line Items]
Related Party Transaction [Line Items]
Annual license fee
Related Party Transaction Amounts Of Transaction
Exclusive license option, thereafter
Payable On Exclusive License Option Thereafter
Development service costs
Software Development Service Costs
Related party transaction, amount paid
Related Party Transaction Expenses From Transactions With Related Party
Operating income/ (loss)
Net income/(loss) per common share, basic
Earnings Per Share Basic
Net income/(loss) per common share, diluted
Earnings Per Share Diluted
Net Loss per common share, basic and diluted
Subsequent Event [Table]
Subsequent Event [Table]
Subsequent Event [Line Items]
Subsequent Event [Line Items]